Have You Ever Thought About the Second Person?

Gianna Liantonio, Verrazzano Class of 2025, completed major in English Writing and minors in ASL and Italian

I wrote a critical analysis on the creative nonfiction essay, "You Are the Second Person" by Kiese Laymon, with Professor Cate Marvin as my mentor. We explored the different themes of the essay such as racism, prejudice, family, health and revelation.

Kiese Laymon wrote about his experience working under a toxic editor for five years to gain his approval, but realized in the end he was not going to get his book published. He decided to put himself first and write what he wanted to write, publishing many books and essays.

He is a strong advocate for Black writers and is authentic in his work, never filtering what he knows is important to be said. He writes from the heart and if it’s not real, it has no business getting published. He wants to be able to stand by his work years later, but said there is no shame in revising over and over. He has revised works that seemed perfect at the time, but wanted to make them even better. He is a hard-working writer who, from this experience, learned the types of books he wants to write and would not let anyone dictate the topics he includes.

I read the essay in Professor Marvin’s creative writing class, and appreciated Laymon’s realistic view of the publishing world that you normally would not hear about. I enjoyed reading and learning about Laymon and his experience and identified with this piece because I hope to one day work in publishing and editing.

I knew I wanted to do a creative writing project of some kind for my capstone and felt Professor Marvin would be the perfect mentor. I enjoyed her class immensely and learned a lot to help me become a better writer.

The capstone was a summary of the essay and delved into different themes we discovered as I was writing. I realized I had more I could write about than I initially thought, gaining new insights each time I read the essay.

The biggest challenge was the page count and being able to write new ideas without repeating myself, and I was surprised with how many pages I ended up with at the end. I did enjoy writing this paper as it helped me interpret the essay in different ways and discover more themes than I initially saw. The easy part was that I enjoyed reading the essay over and over, analyzing different parts, and seeing details I may have missed the first time.

Once I had a steady outline I was able to write a lot, with new ideas blossoming every second. When I did get stuck, Professor Marvin helped me find more aspects of the essay to write about, and that helped me finish it.

Even though Laymon's essay had the same amount of words each time I read it, I gained a new perspective each time. For example, he wrote about a man he observed outside his window. Each time I read it, I thought of different reasons why he included that in this piece.

I could expand this piece with in-depth writing on his other essays and novels, or how there are two sides to the publishing world, one of which is rarely heard about.

What I take away from this research experience is that I feel like I know Kiese Laymon by reading through his words and eyes. The essay was in second person, which had us walk in his shoes during his experience and helped the reader to empathize and understand his situation.

I enjoy analyzing works of literature and finding the deeper meanings behind a line or paragraph. I enjoyed writing this paper and even though it was challenging at times, I had fun delving into different themes and aspects. I want to read more of Laymon’s works and see similarities and differences in his writing. He is a talented writer who writes what he believes no matter what anyone says. 

 

Exploring the Role of Collagens (COL13A1, 14A1, 15A1) in Head and Neck Cancer

 Aisha Yousaf, Verrazzano Class of 2025, completed major in Biology

Conducting my research project on the role of collagen genes in head and neck squamous cell carcinoma (HNSCC) has been an incredibly rewarding academic and personal journey. When I first began this project, I had a general interest in head and neck cancer biology and the roles of the collagen gene family and the extracellular matrix. I didn’t fully realize how much the tumor’s surrounding structure could impact patient survival, treatment outcomes, and even the future of personalized medicine. Through months of literature review, data analysis, and discussions with my mentor, Dr. Nancy Liu-Sullivan, I’ve come to appreciate how complex and dynamic the tumor microenvironment really is.

One of the most important things I learned throughout this process is that cancer research isn’t just about targeting the tumor itself but it’s also about understanding the complex environment in which it exists. I had always thought of collagen as a structural support protein, but through my research, I discovered that different types of collagen can either promote or suppress tumor progression. Investigating COL13A1, COL14A1, and COL15A1 helped me see how even small differences in gene expression can impact overall survival for patients with HNSCC. It was both eye opening and empowering to work with real world RNA-seq data and generate Kaplan-Meier survival plots to draw meaningful conclusions about cancer outcomes.

Beyond the science, this project taught me the importance of staying curious, being persistent, and learning from mentors. The support I received helped me think more clearly, ask better questions, and solve problems in a more thoughtful way. I now feel more confident reading scientific articles, working with data, and talking about cancer biology and treatment. Most importantly, this research has motivated me to keep studying how diseases work at the molecular level and explore how discoveries in the lab/research studies can improve patient care.

Analysis of EGFR/RAS Isoforms in Melanoma and Effects of PKI-166 on EGFR

Abedalfattah Twam, Verrazzano Class of 2025, completed major in Biology

My research goal was to look into melanoma and how expression levels of different oncogenes can impact patient prognostics. The oncogenes I chose for this study were EGFR and the isoforms of RAS which consist of Kras, Hras and Nras. Using the Kaplan Meier database, I found that higher expression levels from EGFR and Hras were associated with shorter survival times in patients with melanoma whereas Kras and Nras expression levels were found to have no significant impact. Additionally, I also researched PKI-166. PKI-166 was a drug which had inhibitory effects on EGFR reducing its activities, however it had many adverse effects leading to it being discontinued.

I chose this area of research because I strive to become a future healthcare provider. I believe the knowledge I learned from taking on this research and also the skills I've developed throughout will help me as a future provider. Reading through a variety of publications and using resources like google scholars to find relevant information was a major challenge and at times very exhausting, it taught me just how challenging researching can be and the amount of patience needed. If I were to ever go back and add to my research I would like to study which oncogenes are found to impact melanoma patient prognostics, how common these oncogenes are and possible treatment options.

Overall, this experience was challenging but very rewarding!

PKI-166 Structure

The Impact of Vision Impairment on Development and Daily Life in Young Adults & Children

Merna Mikhail, Verrazzano Class of 2025, completed major in Psychology

For my capstone project, I chose to research a topic that deeply interests me and aligns with my career goals. I aimed to combine my psychology major with my goal of becoming an optometrist by exploring vision impairment and its impact on the development and daily life in children and young adults. The objective of my research was to gain a deeper understanding of how adolescents and children with vision impairments navigate their daily lives, including the challenges and limitations they may face whether in school, social relationships, or personal development. Additionally, I wanted to explore how vision impairment influences self-esteem and confidence, which can have broader effects on various aspects of life.

During my literature review, I came across some unexpected findings. For instance, one study revealed that adolescents with severe vision impairments reported the highest sense of school belonging compared to their sighted peers and those with milder visual impairments. This was surprising because one might assume that greater vision impairment would correlate with increased struggles in social integration.

However, this study challenged that assumption, highlighting the complexity of individual experiences. One of the most significant takeaways from my research is that no two cases are the same; there is no universal standard for how vision impairment affects a person’s life. Each individual experiences and copes with their impairment differently. Some grow up in supportive environments that encourage independence, while others may not have access to the same resources or support, leading to greater feelings of limitation. Through my research, I also discovered various tools, such as assistive apps, that help individuals with vision impairments navigate daily challenges.

Pursuing a career in optometry means that I will work with a diverse range of patients, including children and adolescents with varying degrees of vision impairment. This research has provided me with valuable insight into their experiences, challenges, and coping mechanisms. Additionally, it has broadened my perspective on how society can better support individuals with vision impairments.

Initially, I expected my capstone to be just another project, something to complete and move on from. However, it turned out to be a profoundly eye-opening experience that provided me with new perspectives and meaningful knowledge. One of the biggest challenges I faced was finding the right sources, as locating relevant and credible studies required extensive research. Fortunately meeting with my mentor, Professor Louis Rotondo, helped me refine my focus and identify key areas to explore.

Looking ahead, I would love to expand this research by shifting the focus to adults with vision impairments. Understanding how they manage daily life, their self-perceptions, and their coping strategies could provide even more valuable insight into the lifelong impact of vision impairment.

Ultimately, this experience has reinforced the importance of being open to learning and embracing the unexpected. I now understand that research is not just about finding answers but about uncovering new perspectives that challenge assumptions. This project has been both enlightening and rewarding, and I look forward to applying what I’ve learned in my future career.

Visualizing interactions between RAGE and S100A12 binding and signaling with YFP and CFP

Shaan Shirazi, Verrazzano Class of 2025, completed major in Biology

I was looking for research and was accepted to work in Dr. Rupal Gupta’s lab. There was definitely a learning curve for me, as the projects involved relied heavily on topics in biology and biochemistry that I hadn’t yet learned.

But from the very beginning, I was fascinated by the work being done on proteins and how the experiments conducted could help further our knowledge on the intricate systems that help our bodies function. This was a big motivating factor that kept me coming back and working in the lab. I loved how the work I did would actually help us to work towards a goal of publishing our findings on different proteins and receptors in our bodies, furthering society’s knowledge on this topic.

My capstone covers how my research aims to understand how a protein in our body named S100A12 interacts with its respective receptor called RAGE. Using a technique called fluorescent energy transfer microscopy, it uses a fluorescent protein that we attached to the receptors to visually observe and detect the interactions between S100A12 and RAGE. S100A12 is normally produced by our immune system, and is known to signal immune responses via RAGE, such as inflammation. S100A12 is observed in patients suffering inflammation from diseases such as chronic kidney disease and rheumatoid arthritis.

I found it challenging yet fun learning how to operate different machinery such as the thermocycler to replicate DNA via polymerase chain reaction (PCR) or the gel electrophoresis system to confirm the presence of DNA. I began my research with a basic knowledge on their function and purpose and came out far more experienced and learned. Experiences like that actually benefited me in my biology classes, when these techniques were discussed and tested on.

Working on this project I was very surprised at the time many procedures took, as I quickly learned that science requires a lot of time and patience to get results, and that I always have to brace myself for failure as that is much more common than success. In my capstone paper I detail in my results section the many hiccups I encountered when working towards my goal, and every time I learned to stand back and assess what went wrong and adjust my methods accordingly.

I began this project in my sophomore year, and I have since heavily expanded upon my research on this specific topic involving the S100A12 protein, testing different mutants such as S100A12E31A and S100A12E31AI47A’s ability to bind metal under different conditions. Overall in addition to the scientific knowledge I have gained working on this project, more importantly, I also learned a lot of good skills and habits such as patience, work ethic, and critical thinking.