Tashia Seneviratne, Verrazzano Class of
2024, completed major in Biology
Research
literature reviews on particular subjects, including ketamine and its possible
effects on kidney function and chronic pain, can be insightful and beneficial.
Since ketamine has generated interest for its possible analgesic qualities and
its impact on renal function, I expected to find a substantial quantity of
previous study on the subject. I also anticipated seeing a range of study
designs, such as observational studies, clinical trials, and systemic reviews.
I gained a lot of knowledge about the current status of research on ketamine's
effects on renal function and chronic pain while doing a literature study.
I
learned that ketamine has demonstrated promise as a possible treatment for
chronic pain disorders, despite being best recognized as an anesthetic and
recreational medication. According to the majority of research, ketamine may
reduce pain through influencing the N-methyl-D-aspartate (NMDA) receptor, which
is involved in the transmission of pain. Moreover, studies I read suggested
that ketamine has complex and varied impacts on renal function. Ketamine could
prove to be advantageous in a variety of ways such as NMDA receptor
modulation, central sensitization, anti-inflammatory effects and
neuroplasticity which is when the brain adapts to changes. Ketamine is usually
administered in small doses for chronic pain than when it is used for other
purposes such as general anesthesia. It can be administered through many
methods such as the oral route, nasal sprays, intravenously and topical creams.
The NMDA receptor is important in controlling synaptic change, learning, and
memory in addition to transmitting pain signals. As an NMDA receptor
antagonist, ketamine blocks the receptor's ability to function. Ketamine binds
to these NMDA receptors and acts as an antagonistic of NMDA. Ketamine can
potentially lessen pain perception by changing the transmission of pain signals
in this way.
While some research has indicated that
ketamine use may cause kidney damage, other studies have indicated that the
drug may not have a significant or even positive effect on renal function. When
interpreting the results, it is essential to recognize the subtle differences
and the limitations of the available evidence. As I read through academic
literature through OneSearch accessed by the CUNY library, I came across some
unexpected and surprising discoveries. For example, I found contradictory
results from several studies, which emphasize the need for greater
investigation and a deeper comprehension of the subject. Furthermore, research
has been conducted on the possible advantages of ketamine in the treatment of
chronic pain problems, like limb ischaemia, which I was not previously aware
of.
Completing
a study literature review helped me grow personally by improving my
analytical and critical thinking abilities. It enabled me to gain a
greater comprehension of research techniques, the scientific method, and the
significance of evidence-based practice. In addition, performing a literature
review can help me become more skilled at combining data from many sources and
clearly communicating complicated concepts.
In
conclusion, performing a research literature study for the capstone on ketamine
and kidney/chronic pain is rewarding. It enabled me to expand my
critical thinking abilities, obtain an in-depth understanding of the subject,
and contribute to progress within the field of science and this topic.